Perfect intro, it really sets the classic Pico tone. It's rather clear this is a comedy from the first line. The different animation styles were complementary to this animation and I see that you used the classic background blur technique. I'm going to assume the microphone feedback effect was intentional. However, it does come off as ear rapey so you may want to watch out for that in later animations. The scene at 1:41 was okay, but the dialogue seemed to lack emotion and just got cringey as the line delivery seemed forced and unrealistic. Yes, I understand this is a comedy, but it doesn't seem natural or even exaggerated, just bland. In the Tom Fulp birthday scene, the lip sync was...not synced well, but seeing as this is a comedy, I'll let that slide. Nonetheless, the dialogue and lines were okay, but again, the microphone feedback breathing just ruined it. Now for the scene where Pico is staring at the computer. I like the background and character design as well as the facial expressions used and the music. The lines were complementary to the characters. That one was perfect. The next scene, the background was cool, the line delivery was great, the animation for the characters actions and facial expressions were excellent. I especially liked the pupils and how they reacted in correspondence to the line delivery. The credits scene was a cool compilation with lots of easter eggs.
Seeing as this is a comedy, I'll let lots of my critiques slide, the biggest things were really audio issues and some dialogue/lip sync errors. Other than that, this was well put together. Fantastic work!